[ADA2013]纪立农：中国新诊断2型糖尿病患者心血管风险较高
发布时间：2013-06-28 | 来源：医脉通
关键词：
2型糖尿病
心血管风险
新诊断2型糖尿病
ADA2013
第73届美国糖尿病协会科学年会
【导语】2013年第73届美国糖尿病协会科学年会(ADA2013)于6月21日~25日在美国芝加哥隆重举办，在ADA2013年会上，北京大学第一医院纪立农教授有5篇中国研究入选壁报讨论(2篇 General Poster Sessions)和会议摘要(3篇 Published Only)。其中一篇会议摘要题目为“中国新诊断2型糖尿病患者的治疗有效性评估(NEW2D)”，研究结果显示中国新诊断2型糖尿病患者的心血管风险较高，在降低血糖的同时，预防心血管及其他糖尿病并发症也是当务之急。以下是医脉通对相关内容的翻译整理。
2型糖尿病患者的血管并发症风险增加，预防措施之一是在早期进行积极的干预。中国新诊断2型糖尿病患者研究(NEW2D)是中国心血管代谢研究(CCMR)的一部分，旨在了解这部分糖尿病患者的治疗模式及其有效性。
在6个月内诊断2型糖尿病的成年患者(超过20岁)纳入研究。基线时收集其人口统计学资料(包括社会经济状况及诊断模式)、合并用药情况、低血糖发生率，进行体格检查、实验室检查。其后每三个月进行随访，共计12个月。
在首期入选的2766人中，54.1%为男性，平均年龄55.5+12.2岁(10.2% 的患者小于40岁， 24.3% 的患者大于65岁)。61%患有高血压、高血脂其中的一种。12.4%已经存在血管并发症。67%有两个或以上的心血管危险因素(图 1)。基线时糖化血红蛋白为8.4+2.6 %，39.1%的患者糖化血红蛋白小于7%，51%的患者正在使用一种或几种口服降糖药(OAD)，27%的患者正在使用胰岛素治疗(单独或与口服药联用)，22%未使用任何药物治疗。
初步研究结果显示中国新诊断2型糖尿病患者的心血管风险较高，在降低血糖的同时，预防心血管及其他糖尿病并发症也是当务之急。
【研究摘要】
Evaluating the Effectiveness of Treatment in Newly Diagnosed Type 2 Diabetics in China (NEW2D)
Linong Ji MD, Peking University
Type 2 diabetes mellitus (T2DM) is associated with an increased risk for vascular complications. Intense management at early stage of T2DM is an important strategy for preventing vascular complications.
The NEW2D Study was designed as part of the China Cardiometabolic Registries (CCMR) to assess the treatment pattern and effectiveness in newly diagnosed T2DM patients.
Patients (> 20 years of age) diagnosed with T2DM within 6 months were eligible for enrollment. Patient demographics socio-economic status and diagnosis pattern were collected at baseline; physical evaluation medical history lab results concurrent medications and experience of hypoglycemia were collected at baseline and every 3 months thereafter for 12 months.
Among the first 2766 of the 5000 patients enrolled: 54.1% were male mean age was 55.5+12.2 years (10.2% of patients < 40 years 24.3% of patients > 65 years); 61% had prior hypertension hyperlipidemia or both; 12.4% had pre-existing vascular complications; 67% presented with 2 or more CVD risk factors (Fig 1). At baseline the mean HbA1c was 8.4+2.6 %; 39.1% of the patients had HbA1c <7% 51% were being treated with one or more oral anti-diabetic drug(s) (OAD); 27% with insulin (alone or in combination with OAD); and 22% with no drug treatment.
Initial results showed that the majority of newly diagnosed T2DM patients are at high risk for CVD. While improving glycemic control prevention of CVD and other diabetic complications should be a priority.
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