ACC.26前瞻丨7场最新突破性临床试验,5场特色临床试验即将揭晓,点亮心血管诊疗前沿方向
2026-01-26


北京时间3月28日-30日,第75届美国心脏病学会科学年会(ACC.26)即将在美国新奥尔良隆重召开。这场为期三天的全球心血管顶级学术盛宴亮点纷呈,7场LBCT突破性临床试验、5场特色临床试验专场轮番登场,海量前沿成果即将揭晓。本文将提前解码会议亮点,前瞻这场学术盛宴的核心看点。


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作者:Xuemei Guo


7场最新突破性临床试验


01


Late-Breaking Clinical Trials I

北京时间:3月28日 23:30-00:30

Ultrasound-Facilitated Catheter-Directed Thrombolysis Vs Anticoagulation Alone For Acute Intermediate-High-Risk Pulmonary Embolism: Primary Results of the HI-PEITHO Randomized Clinical Trial

HI-PEITHO随机临床试验主要结果:急性中高危肺栓塞超声辅助导管导向溶栓 vs. 单纯抗凝治疗

讲者:Stavros V. Konstantinides


Outcomes in Patients With Atrial Fibrillation Randomized to Receive Left Atrial Appendage Closure or Oral Anticoagulation: Primary Results of the CHAMPION-AF Clinical Trial
CHAMPION-AF临床试验主要结果:随机接受左心耳封堵术或口服抗凝治疗的房颤患者结局

讲者:Saibal Kar


Primary Left Ventricular Unloading in Anterior ST-Segment Elevation Myocardial Infarction (STEMI) Without Cardiogenic Shock: Results From the STEMI-Door to Unload Randomized Clinical Trial

STEMI-Door to Unload随机临床试验结果:无心源性休克的前壁ST段抬高型心肌梗死(STEMI)患者早期行左心室减负荷治疗的疗效及安全性

讲者:Navin Kapur


02


Late-Breaking Clinical Trials II

北京时间:3月29日 5:45-6:45

Kardinal: A Phase 2 Study of Tonlamarsen For the Treatment of Uncontrolled Hypertension 
KARDINAL 2期临床试验:评估Tonlamarsen治疗未控制高血压的疗效和安全性

讲者:Luke Laffin


Evolocumab in Patients Without Significant Atherosclerosis: Results From VESALIUS-CV
VESALIUS-CV试验结果:依洛尤单抗在无显著动脉粥样硬化患者中的应用
讲者:Nicholas Marston


Intensive Low-Density Lipoprotein Cholesterol Targeting in Patients With Atherosclerotic Cardiovascular Disease
动脉粥样硬化性心血管疾病(ASCVD)患者进行强化低密度脂蛋白胆固醇(LDL-C)治疗的目标值设定

讲者:Yong-Joon Lee


DASH-Patterned Groceries to Reduce Blood Pressure Among Adults With Treated Hypertension: Results From the GoFreshRx Randomized Clinical Trial
GoFreshRx随机临床试验结果:经治疗的高血压成人进行DASH模式饮食的降压疗效

讲者:Stephen Paul Juraschek


03


Late-Breaking Clinical Trials III

北京时间:3月29日 22:30-23:30

Controlled Trial of High-Risk Coronary Intervention With Percutaneous Left Ventricular Unloading (CHIP-BCIS3)

CHIP-BCIS3对照试验:高危冠状动脉介入治疗患者进行经皮左心室减负荷技术的疗效和安全性

讲者:Divaka Perera


A Large-Scale, Global Randomized Trial of Coronary Physiology Derived From Conventional Angiography Compared With An Invasive Pressure Wire-Based Approach to Guide Percutaneous Coronary Intervention
一项大规模全球随机试验:基于常规造影衍生的冠状动脉生理学 vs. 基于有创压力导丝的方法指导经皮冠状动脉介入治疗(PCI)
讲者:Ajay J. Kirtane


A Randomized, Placebo-Controlled Trial of Chronic Total Occlusion Percutaneous Coronary Intervention in Stable Angina- ORBITA-CTO Trial
ORBITA-CTO随机、安慰剂对照试验:对稳定型心绞痛患者的慢性完全闭塞病变行PCI治疗的疗效和安全性
讲者:Sarosh A. Khan


Fractional Flow Reserve or 3d-quantitative Coronary Angiography-Based Vessel-Ffr Guided Revascularization – The Fast Ⅲ Trial
Fast Ⅲ试验:血流储备分数(FFR)或基于3D定量冠状动脉造影的FFR指导血运重建治疗的疗效和安全性

讲者:Joost Daemen


04


Late-Breaking Clinical Trials IV

北京时间:3月30日 00:45-1:45

Spironolactone in the Treatment of Heart Failure

螺内酯治疗心力衰竭的疗效和安全性
讲者:Frank Edelmann


Efficacy and Safety of Sotatercept in Combined Post- and Pre-Capillary Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction: Results From the Phase 2 Cadence Trial
Cadence 2期试验结果:Sotatercept在射血分数保留的心力衰竭(HFpEF)相关的毛细血管前后混合性肺动脉高压治疗中的疗效与安全性

讲者:Mardi Gomberg-Maitland


Lung Impedance-Guided Therapy in Heart Failure With Preserved Ejection Fraction: Results of a Randomized Clinical Trial
一项随机临床试验的结果:基于肺阻抗监测指导HFpEF治疗
讲者:Michael Kleiner Shochat


Mavacamten in Symptomatic Adolescent Patients With Obstructive Hypertrophic Cardiomyopathy: Results From the Phase 3 Scout-HCM Trial
来自Scout-HCM Ⅲ期试验的结果:有症状的青少年梗阻性肥厚型心肌病患者进行玛伐凯泰(mavacamten)

讲者:Joseph William Rossano


05


Late-Breaking Clinical Trials V

北京时间:3月30日 6:00-7:00

Redo-Surgery Versus Transcatheter Valve-In-Valve For Mitral Bioprosthetic Dysfunction: The SURVIV Trial

SURVIV试验:再次外科手术 vs. 经导管瓣中瓣技术治疗二尖瓣生物瓣功能障碍

讲者:Dimytri Siqueira


Transcatheter Aortic Valve Implantation Without Routine Percutaneous Coronary Intervention: A Randomized Controlled Trial

一项随机对照试验:不常规进行PCI的经导管主动脉瓣介入治疗

讲者:Michiel Voskuil


Protect The Head To Head Trial: Randomized Comparison of Emboliner Embolic Protection Catheter Vs. Sentinel Cerebral Protection System During Transcatheter Aortic Valve Replacement
Protect头对头随机对照试验:在经导管主动脉瓣置换术中,Emboliner栓塞保护导管 vs Sentinel脑保护系统的疗效及安全性
讲者:Adam B. Greenbaum


Two-Year Outcomes After Transcatheter Tricuspid Repair Without Cross-over in the Randomized Tri-fr Trial
Tri-Fr随机试验中无交叉治疗的经导管三尖瓣修复术后两年结局
讲者:Erwan Donal


06


Late-Breaking Clinical Trials VI

北京时间:3月30日 22:30-23:30

Heartline Study: A Decentralized Randomized Trial of Apple Watch and iPhone-Facilitated AF Detection and Cardiovascular Outcomes in Older Adults Without Known Atrial Fibrillation

Heartline试验:基于苹果手表与iPhone 辅助房颤筛查的分散式随机试验——无已知房颤病史老年人的心血管结局评估

讲者:C. Michael Gibson


Digoxin in Rheumatic Heart Disease: A Multi-Center, Randomized, Double Blind, Placebo-controlled Trial
一项多中心、随机、双盲、安慰剂对照试验:探究地高辛用于风湿性心脏病患者的疗效及安全性
讲者:Ganesan Karthikeyan


Discontinuation of β-blocker Therapy in Stabilized Patients After Acute Myocardial Infarction

急性心肌梗死后病情稳定患者停用β受体阻滞剂治疗的探索

讲者:Joo-Yong Hahn


Effect of Intensive Triglyceride Lowering With Olezarsen on Progression of Coronary Atherosclerosis: A Coronary Cta Substudy of The Essence-TIMI 73b Randomized Trial
Essence-TIMI 73b随机试验冠脉CTA亚组分析:应用Olezarsen强化降低甘油三酯对冠状动脉粥样硬化进展的影响

讲者:Nicholas Marston


07


Late-Breaking Clinical Trials VII

北京时间:3月31日 00:45-1:45

Primary Efficacy and Safety Results From the Phase 3 Sirolimus-Coated Balloon For Infra-inguinal Peripheral Arterial Disease (SirPAD) Trial

SirPAD Ⅲ期试验主要结果:西罗莫司涂层球囊治疗腹股沟下外周动脉疾病的疗效与安全性
讲者:Stefano Barco


Intravascular Ultrasound Guidance For Complex High-Risk Indicated Procedures – The Ivus Chip Trial
Ivus Chip试验:血管内超声指导复杂高危有指征手术

讲者:Roberto Diletti


Intravascular Ultrasound-Guided Versus Angiography-Guided Percutaneous Coronary Intervention In Unprotected Left Main Coronary Artery Disease – The Optimal Trial
Optimal试验:血管内超声引导对比造影引导的PCI治疗在无保护左主干冠状动脉疾病中的应用
讲者:Adrian Banning


Ivus Or Angiography Guidance For PCI in Complex Coronary Bifurcation Lesions

复杂冠状动脉分叉病变PCI术中血管内超声或血管造影指导

讲者:南京市第一医院 陈绍良



5场特色临床研究


01


Featured Clinical Research I

北京时间:3月29日 02:00-03:00

A Prospective Multicenter Registry to Define Coronary Vasomotor Disorders in Ischemia With Nonobstructive Coronary Arteries: Primary Results of Discover Inoca
DISCOVER INOCA前瞻性多中心注册试验的主要结果:旨在明确非阻塞性冠状动脉缺血中的冠状动脉血管舒缩功能障碍
讲者:Samit M. Shah


Impact of Ivabradine on Orthostatic Intolerance, Quality of Life and Heart Rate in Post-Covid Postural Orthostatic Tachycardia Syndrome: Results From the Recover-Autonomic Trial
Recover-Autonomic试验结果:伊伐布雷定对新冠后体位性心动过速综合征患者直立不耐受、生活质量及心率的影响
讲者:Saibal Kar


Coronary Optical Coherence Tomography and Cardiac Magnetic Resonance Imaging to Determine Sex Differences in Underlying Causes of Myocardial Infarction With No Obstructive Coronary Arteries
应用冠脉光学相干断层扫描与心脏磁共振成像探究非阻塞性冠脉心肌梗死病因的性别差异
讲者:Harmony R. Reynolds


A Sham Controlled Randomised Trial Evaluating the Safety, Acceptability and Efficacy of Autonomic Neuromodulation Using Trans-Cutaneous Vagal Sensory Stimulation in Uncontrolled Hypertensive Patients
一项假刺激对照随机试验:评估经皮迷走神经感觉刺激在未控制高血压患者自主神经调节的安全性、可接受性与有效性
讲者:Ajay K. Gupta


02


Featured Clinical Research II

北京时间:3月29日 03:30-04:30

Effects of Tirzepatide Compared With Dulaglutide on Expanded Cardiorenal Outcomes
Tirzepatide vs. 度拉糖肽对扩展心肾结局的影响

讲者:Steven E. Nissen


Prevalence and Clinical Impact of Hypercortisolism in Individuals With Resistant Hypertension: Primary Results From the Momentum Study
MOMENTUM试验主要结果:在难治性高血压患者中,探究皮质醇增多症的患病率与临床影响
讲者:Deepak L. Bhatt


Reliability of CAC=0 to Exclude Coronary Plaque in Diverse Global Cohorts: A Global Probability Study of Coronary Artery Disease (GPS-CAD) Analysis
全球冠状动脉疾病概率试验(GPS-CAD)数据分析:在不同种族队列中,CAC 0分除外冠脉斑块的可靠性评估
讲者:Lohendran Baskaran


Community-to-Clinic Linkage Implementation Program to Prevent Hypertension in Barbershops
基于理发店的社区:诊所联动高血压预防计划实施研究

讲者:Joseph E. Ravenell


03


Featured Clinical Research III

北京时间:3月30日 02:15-03:15

10-year Follow-up of Clopidogrel Vs Aspirin Monotherapy in Stable Coronary Artery Disease After Percutaneous Coronary Intervention With Drug-eluting Stent
稳定型冠状动脉疾病患者进行药物洗脱支架PCI治疗后,氯吡格雷 vs.阿司匹林单药治疗的10年随访结果
讲者:Hyo-Soo Kim


Coronary CT Derived Fractional Flow Reserve-guided Management of Patients With Stable CAD: 3-year Outcomes From A Multicentre, Pragmatic, Open-label, Randomised Controlled Trial in China
中国多中心、实用性、开放标签、随机对照试验3年结果:冠状动脉CT衍生的FFR指导的稳定型冠状动脉疾病患者管理

讲者:唐春香 中国人民解放军东部战区总医院


Role of Screening With Coronary Computed Tomography Angiography in Lipid Management in an Asymptomatic Chinese Population: A Community-Based, Parallel-Group, Open-Label, Randomized Clinical Trial (RESPECT2)
一项基于社区、平行组、开放标签、随机临床试验(RESPECT2):冠脉CTA筛查在无症状中国人群血脂管理中的作用

讲者:郭翔 中国人民解放军东部战区总医院


Targeted Assessment in High-Risk Patients With Diabetes to Identify Undiagnosed Heart Failure
对高风险糖尿病患者进行针对性评估以识别未确诊的心衰

讲者:Daniel Taylor-Sweet


04


Featured Clinical Research IV

北京时间:3月30日 03:45-04:45

Automated Notifications to Improve Referral and Treatment of Severe Aortic Stenosis and Mitral Regurgitation: Outcomes From the Randomized Alert Trial
ALERT随机试验结果:自动化通知改善重度主动脉瓣狭窄和二尖瓣反流的转诊与治疗

讲者:Wayne B. Batchelor


A Randomized Controlled Trial of a Novel Just-in-Time Adaptive Mobile Application Intervention to Reduce Sodium Intake and Blood Pressure in Patients With Hypertension

一项随机对照试验:探究新型即时适应性移动应用程序干预对降低高血压患者钠摄入及血压的影响

讲者:Michael Dorsch


NOTIFY-HF: A Randomised Pilot Trial of Patient-Facing Heartlogic Alerts in Heart Failure Patients
NOTIFY-HF试验:一项面向心衰患者HeartLogic警报的随机试点试验
讲者:Joseph Assad


MUTTON-HF (Medically Utilized Tailored Traditional Foods to Optimize Nutrition in Heart Failure): A Randomized Controlled Trial of an Indigenous Food is Medicine Intervention
MUTTON-HF本土化、随机对照试验:医疗化应用定制传统食物(食物即药物),以优化心衰营养

讲者:Lauren A. Eberly


05


Featured Clinical Research V

北京时间:3月30日 6:00-7:00

Two-Year Outcomes of Transcatheter Tricuspid Valve Replacement For Severe Tricuspid Regurgitation: The TRISCEND II Randomized Trial
TRISCEND II 随机试验:经导管三尖瓣置换治疗重度三尖瓣反流的两年结果

讲者:Vinod H. Thourani


Efficacy and Safety of BHB/HRS-1893 in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Results From A 12-week Phase 2 Study

一项为期12周的2期试验结果:探究BHB/HRS-1893在有症状的梗阻性肥厚型心肌病中的疗效与安全性

讲者:康连鸣 中国医学科学院阜外医院


The Role of Atrial Pacing Support in Cardiac Resynchronization Therapy: A Non-inferiority Randomized Trial
一项非劣效性随机试验:心房起搏支持在心脏再同步化治疗中的作用
讲者:Mauro Biffi


Prehospital Heparin Administration in Patients With STEMI Undergoing Primary PCI
行直接PCI治疗的STEMI患者,院前肝素给药的疗效和安全性探究
讲者:Misa Fister


信源:ACC官网


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