第49届欧洲糖尿病研究协会年会(EASD2013)于9月23-27日在西班牙巴塞罗那召开。当地时间9月24日下午，在 “管理和监测糖尿病(Managing and monitoring diabetes: who does well and who doesn't?)”壁报讨论专场上，英国爱丁堡大学Sarah Wild博士介绍的一项涉及12个国家的研究数据显示，
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| Sarah Wild博士 |
研究纳入来自12个国家(澳地利，丹麦，德国，意大利，拉脱维亚，新西兰，挪威，苏格兰，斯洛文尼亚瑞典，乌克兰，美国)共142
260名儿童和成年1型糖尿病患者。按年龄分为<15岁、15~29岁以及≥30岁三组，评估所有患者在初始1~2年血糖控制的情况，比较这三组人群在校正年龄和糖尿病病程之后，女性和男性患者HbA1c ≥7.5% (58mmol/mol)的比例。
研究者们发现，15-29岁和≥30岁的女性1型糖尿病患者，HbA1c ≥7.5%的比例分别为8%和6%，相比同年龄段的男性患者，其血糖控制更不易达标。在年龄<15岁的患者中，女性HbA1c ≥7.5%(58mm/mol)的校正风险比更高。在15-29岁和≥30岁的的患者中，这一比值分别为1.08和1.06。
Sarah
Wild博士表示，相比男性，女性1型糖尿病患者的血糖更不易控制。出现这一现象的原因可能与女性患者往往有较低的
研究摘要：
| Sex differences in glycaemic control among people with type 1 diabetes |
| Background and aims: There are limited data describing whether control of type 1 diabetes differs between the sexes. Our aim was to investigate this issue using a large international dataset. Materials and methods: This analysis represents an international collaboration based on data for 142,260 children and adults with type 1 diabetes, defined using the best available criteria for each country, from 12 countries in total (Austria, Denmark, Germany, Italy, Latvia, New Zealand, Norway, Scotland, Slovenia, Sweden, Ukraine, United States) on glycaemic control over the previous 12 to 24 months derived from both population-based registers and clinic databases. Logistic regression was used to generate odds ratios (ORs) and 95% confidence intervals (CI) for HbA1c ≥7.5% (58 mmol/mol) for females compared to males adjusted for age and duration of diabetes within three age strata that broadly represent paediatric (<15 years), young adult (15-29 years) and adult populations (≥30 years). Results: Proportions of people with HbA1c ≥7.5% (58 mmol/mol) ranged from 64.4% in boys <15 years of age to 74.0% in women of 15-29 years old. In the youngest age strata there was no statistically significant difference in odds of HbA1c ≥7.5% (58 mmol/mol) between boys and girls: adjusted OR 1.05, 95% CI: 1.00-1.10 (n=15304 boys and 14423 girls). In the two older age categories, women had statistically significantly higher adjusted odds ratios (AOR) for HbA1c ≥7.5% (58 mmol/mol) (15-29 years AOR 1.08, 95% CI: 1.02-1.13 (n=19799 men and 17012 women); ≥30 years AOR 1.06, 95% CI: 1.02-1.10 (n=40388 men and 33241 women)). Conclusion: In this cross-sectional analysis of type 1 diabetes data from several countries females were more likely to have an HbA1c ≥7.5% (58 mmol/mol) than males. Further work is required to investigate explanations for this finding. |
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